Cancer cells cue the p 53 response of cancer - associated fibroblasts ( CAFs ) to cisplatin
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چکیده
Jens O Schmid, Meng Dong, Silke Haubeiß, Godehard Friedel, Sabine Bode, Andreas Grabner, German Ott, Thomas E Mürdter, Moshe Oren, Walter E Aulitzky, Heiko van der Kuip 1 Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Auerbachstr. 112, 70376 Stuttgart, Germany 2 Klinik Schillerhöhe, Department of Thoracic Surgery, Gerlingen, Germany 3 Department of Clinical Pathology, Robert Bosch Hospital, Auerbachstr. 110, 70376 Stuttgart, Germany 4 Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel 5 2 Department of Internal Medicine, Oncology and Hematology, Robert Bosch Hospital, Auerbachstr. 110, 70376 Stuttgart, Germany
منابع مشابه
Cancer cells cue the p53 response of cancer-associated fibroblasts to cisplatin.
Current understanding of the p53 response is based mainly upon in vitro studies of homogeneous cell populations. However, there is little information on whether the same principles operate within heterogeneous tumor tissues that are comprised of cancer cells and other cell types, including cancer-associated fibroblasts (CAF). Using ex-vivo tissue cultures, we investigated p53 status and respons...
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Current understanding of the p53 response is based mainly upon in vitro studies of homogeneous cell populations. However, there is little information on whether the same principles operate within heterogeneous tumor tissues that are comprised of cancer cells and other cell types, including cancer-associated fibroblasts (CAF). Using ex-vivo tissue cultures, we investigated p53 status and respons...
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تاریخ انتشار 2012